Current status of endoscopic full-thickness resection for treatment of colorectal neoplastic lesions
Přemysl Falt Orcid.org 1,2
+ Affiliation
Summary
Endoscopic full-thickness resection (FTR) is a novel technique for endoscopic treatment of colorectal neoplastic lesions that are not suitable for standard endoscopic resection. Published evidence on FTR suggests high technical success rate, high proportion of R0 resections and low risk of serious complications. According to limited data, FTR appears to be a recommendable alternative to the technically challenging and time consuming endoscopic submucosal dissection (ESD) in the treatment of carcinomas with superficial submucosal invasion and local residual neoplasia, specifically outside the rectum. The main limitations of FTR are the limited extent of resection and occasional residual neoplasia after resection. Further research including prospective and randomized comparison to other resection techniques is needed for a correct inclusion of FTR in the treatment algorithm of colorectal neoplasia.
Keywords
colonoscopy, colorectal carcinoma, endoscopic full-thickness resection, endsocopic submucosal dissectionTo read this article in full, please register for free on this website.
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Literature
1. Schmidt A, Meier B, Caca K. Endoscopic full-thickness resection: current status. World J Gastroenterol 2015; 21(31): 9273–9285. doi: 10.3748/wjg.v21.i31.9273.
2. Schmidt A, Damm M, Caca K. Endoscopic full-thickness resection using a novel over-the-scope device. Gastroenterology 2014; 147(4): 740–742. doi: 10.1053/j.gastro.2014.07. 045.
3. Valli PV, Kaufmann M, Vrugt B et al. Endoscopic resection of a diverticulum-arisen colonic adenoma using a full-thickness resection device. Gastroenterology 2014; 147(5): 969–971. doi: 10.1053/j.gastro.2014.07.053.
4. Falt P, Urban O, Hanousek M et al. “Full-thickness” endoskopická resekce lokální reziduální neoplazie v hepatální flexure – videokazuistika. Gastroent Hepatol 2016; 70(5): 398–401. doi: 10.14735/amgh2016398.
5. Ferlitsch M, Moss A, Hassan C et al. Colorectal polypectomy and endoscopic mucosal resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline. Endoscopy 2017; 49(3): 270–297. doi: 10.1055/s-0043-102569.
6. Valli PV, Mertens J, Bauerfeind P. Safe and successful resection of difficult GI lesions using a novel single-step full-thickness resection device (FTRD®). Surg Endosc 2018; 32(1): 289–299. doi: 10.1007/s00464-017-5676-9.
7. Schmidt A, Beyna T, Schumacher B et al. Colonoscopic full-thickness resection using an over-the-scope device: a prospective multicentre study in various indications. Gut 2018; 67(7): 1280–1289. doi: 10.1136/gutjnl-2016-313 677.
8. van der Spek B, Haasnoot K, Meischl C et al. Endoscopic full-thickness resection in the colorectum: a single-center case series evaluating indication, efficacy and safety. Endosc Int Open 2018; 6(10): E1227–E1234. doi: 10.1055/a-0672-1138.
9. Andrisani G, Soriani P, Manno M et al. Colo-rectal endoscopic full-thickness resection (EFTR) with the over-the-scope device (FTRD®): a multicenter Italian experience. Dig Liver Dis 2018; 51(3): 375–381. doi: 10.1016/j.dld.2018.09.030.
10. Falt P, Fojtik P, Hucl T et al. Endoscopic full-thickness resection of the colorectal lesions – a Czech multicenter experience. Endoscopy 2019; 51(4): S137–S138. doi: 10.1055/s-0039-1681574.
11. Ichkhanian Y, Vosoughi K, Diehl DL et al. A large multicenter cohort on the use of full-thickness resection device for difficult colonic lesions. Surg Endosc 2021; 35(3): 1296–1306. doi: 10.1007/s00464-020-07504-9.
12. Falt P, Zapletalova J, Urban O. Endoscopic full-thickness resection versus endoscopic submucosal dissection in the treatment of colonic neoplastic lesions </= 30 mm-a single-center experience. Surg Endosc 2021. doi: 10.1007/s00464-021-08492-0.
13. Meier B, Stritzke B, Kuellmer A et al. Efficacy and safety of endoscopic full-thickness resection in the colorectum: results from the German colonic FTRD registry. Am J Gastroenterol 2020; 115(12): 1998–2006. doi: 10.14309/ ajg.0000000000000795.
14. Zwager LW, Bastiaansen BA, Bronzwaer ME et al. Endoscopic full-thickness resection (eFTR) of colorectal lesions: results from the Dutch colorectal eFTR registry. Endoscopy 2020; 52(11): 1014–1023. doi: 10.1055/a-1176-1107.
15. Falt P, Hucl T, Fojtik P et al. Endoskopická transmurální resekce v terapii lokálních reziduálních neoplázií – analýza souboru 19 pacientů. Gastroent Hepatol 2018, 72(3): 206–211. doi: 10.14735/amgh2018206.
16. Kuellmer A, Mueller J, Caca K et al. Endoscopic full-thickness resection for early colorectal cancer. Gastrointest Endosc 2019; 89(6): 1180–1189. doi: 10.1016/j.gie.2018.12.025.
17. Oliviero G, Gagliardi M, Napoli M et al. Fatal outcome consequent to an endoscopic full thickness resection of a colonic lateral spreading tumor: a case report. Am J Case Rep 2020. doi: 10.12659/AJCR.922855.
18. Schmidbaur S, Wannhoff A, Walter B et al. Risk of appendicitis after endoscopic full-thickness resection of lesions involving the appendiceal orifice: a retrospective analysis. Endoscopy 2021; 53(4): 424–428. doi: 10.1055/a-1227-4555.
19. Dumoulin FL, Gorris DG, Berger S et al. Full-thickness resection with an over-the-scope device: possible translocation of adenoma tissue in a case of an incomplete resection at the appendix. Endosc Int Open 2018; 6(5): E622–E624. doi: 10.1055/a-0589-9850.
20. Falt P, Stepan M, Andelova R et al. Combination of endoscopic mucosal resection and full-thickness resection in the treatment of local residual neoplasia of the colon two case reports. Rozhl Chir Fall 2017; 96(9): 394–398.
21. Falt P, Andělová R, Urban O. Kombinace endoskopické slizniční resekce a „full-thickness“ resekce v léčbě adenomu ascendens s příznakem „non-liftingu“. Gastroent Hepatol 2018; 72(2): 148–151. doi: 10.14735/amgh2018csgh.info03.
22. Meier B, Caca K, Schmidt A. Hybrid endoscopic mucosal resection and full-thickness resection: a new approach for resection of large non-lifting colorectal adenomas (with video). Surg Endosc 2017; 31(10): 4268–4274. doi: 10.1007/s00464-017-5461-9.
23. Akintoye E, Kumar N, Aihara H et al. Colorectal endoscopic submucosal dissection: a systematic review and meta-analysis. Endosc Int Open 2016; 4(10): E1030–E1044. doi: 10.1055/s-0042-114774.
24. Clinical Trials. Endoscopic full thickness resection versus standard therapy of the colorectal neoplasia. 2019 [online]. Available from: https: //clinicaltrials.gov/ct2/show/NCT 03868605.
2. Schmidt A, Damm M, Caca K. Endoscopic full-thickness resection using a novel over-the-scope device. Gastroenterology 2014; 147(4): 740–742. doi: 10.1053/j.gastro.2014.07. 045.
3. Valli PV, Kaufmann M, Vrugt B et al. Endoscopic resection of a diverticulum-arisen colonic adenoma using a full-thickness resection device. Gastroenterology 2014; 147(5): 969–971. doi: 10.1053/j.gastro.2014.07.053.
4. Falt P, Urban O, Hanousek M et al. “Full-thickness” endoskopická resekce lokální reziduální neoplazie v hepatální flexure – videokazuistika. Gastroent Hepatol 2016; 70(5): 398–401. doi: 10.14735/amgh2016398.
5. Ferlitsch M, Moss A, Hassan C et al. Colorectal polypectomy and endoscopic mucosal resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline. Endoscopy 2017; 49(3): 270–297. doi: 10.1055/s-0043-102569.
6. Valli PV, Mertens J, Bauerfeind P. Safe and successful resection of difficult GI lesions using a novel single-step full-thickness resection device (FTRD®). Surg Endosc 2018; 32(1): 289–299. doi: 10.1007/s00464-017-5676-9.
7. Schmidt A, Beyna T, Schumacher B et al. Colonoscopic full-thickness resection using an over-the-scope device: a prospective multicentre study in various indications. Gut 2018; 67(7): 1280–1289. doi: 10.1136/gutjnl-2016-313 677.
8. van der Spek B, Haasnoot K, Meischl C et al. Endoscopic full-thickness resection in the colorectum: a single-center case series evaluating indication, efficacy and safety. Endosc Int Open 2018; 6(10): E1227–E1234. doi: 10.1055/a-0672-1138.
9. Andrisani G, Soriani P, Manno M et al. Colo-rectal endoscopic full-thickness resection (EFTR) with the over-the-scope device (FTRD®): a multicenter Italian experience. Dig Liver Dis 2018; 51(3): 375–381. doi: 10.1016/j.dld.2018.09.030.
10. Falt P, Fojtik P, Hucl T et al. Endoscopic full-thickness resection of the colorectal lesions – a Czech multicenter experience. Endoscopy 2019; 51(4): S137–S138. doi: 10.1055/s-0039-1681574.
11. Ichkhanian Y, Vosoughi K, Diehl DL et al. A large multicenter cohort on the use of full-thickness resection device for difficult colonic lesions. Surg Endosc 2021; 35(3): 1296–1306. doi: 10.1007/s00464-020-07504-9.
12. Falt P, Zapletalova J, Urban O. Endoscopic full-thickness resection versus endoscopic submucosal dissection in the treatment of colonic neoplastic lesions </= 30 mm-a single-center experience. Surg Endosc 2021. doi: 10.1007/s00464-021-08492-0.
13. Meier B, Stritzke B, Kuellmer A et al. Efficacy and safety of endoscopic full-thickness resection in the colorectum: results from the German colonic FTRD registry. Am J Gastroenterol 2020; 115(12): 1998–2006. doi: 10.14309/ ajg.0000000000000795.
14. Zwager LW, Bastiaansen BA, Bronzwaer ME et al. Endoscopic full-thickness resection (eFTR) of colorectal lesions: results from the Dutch colorectal eFTR registry. Endoscopy 2020; 52(11): 1014–1023. doi: 10.1055/a-1176-1107.
15. Falt P, Hucl T, Fojtik P et al. Endoskopická transmurální resekce v terapii lokálních reziduálních neoplázií – analýza souboru 19 pacientů. Gastroent Hepatol 2018, 72(3): 206–211. doi: 10.14735/amgh2018206.
16. Kuellmer A, Mueller J, Caca K et al. Endoscopic full-thickness resection for early colorectal cancer. Gastrointest Endosc 2019; 89(6): 1180–1189. doi: 10.1016/j.gie.2018.12.025.
17. Oliviero G, Gagliardi M, Napoli M et al. Fatal outcome consequent to an endoscopic full thickness resection of a colonic lateral spreading tumor: a case report. Am J Case Rep 2020. doi: 10.12659/AJCR.922855.
18. Schmidbaur S, Wannhoff A, Walter B et al. Risk of appendicitis after endoscopic full-thickness resection of lesions involving the appendiceal orifice: a retrospective analysis. Endoscopy 2021; 53(4): 424–428. doi: 10.1055/a-1227-4555.
19. Dumoulin FL, Gorris DG, Berger S et al. Full-thickness resection with an over-the-scope device: possible translocation of adenoma tissue in a case of an incomplete resection at the appendix. Endosc Int Open 2018; 6(5): E622–E624. doi: 10.1055/a-0589-9850.
20. Falt P, Stepan M, Andelova R et al. Combination of endoscopic mucosal resection and full-thickness resection in the treatment of local residual neoplasia of the colon two case reports. Rozhl Chir Fall 2017; 96(9): 394–398.
21. Falt P, Andělová R, Urban O. Kombinace endoskopické slizniční resekce a „full-thickness“ resekce v léčbě adenomu ascendens s příznakem „non-liftingu“. Gastroent Hepatol 2018; 72(2): 148–151. doi: 10.14735/amgh2018csgh.info03.
22. Meier B, Caca K, Schmidt A. Hybrid endoscopic mucosal resection and full-thickness resection: a new approach for resection of large non-lifting colorectal adenomas (with video). Surg Endosc 2017; 31(10): 4268–4274. doi: 10.1007/s00464-017-5461-9.
23. Akintoye E, Kumar N, Aihara H et al. Colorectal endoscopic submucosal dissection: a systematic review and meta-analysis. Endosc Int Open 2016; 4(10): E1030–E1044. doi: 10.1055/s-0042-114774.
24. Clinical Trials. Endoscopic full thickness resection versus standard therapy of the colorectal neoplasia. 2019 [online]. Available from: https: //clinicaltrials.gov/ct2/show/NCT 03868605.