Pharmacological characteristics of subcutaneously administered monoclonal antibodies
Karel Urbánek Orcid.org 1
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Summary
Subcutaneous administration is a simple method of parenteral administration with a minimum of possible complications, also suitable for home treatment. Moreover, it can be used to influence the pharmacokinetics of the administered drug. For therapeutically used monoclonal antibodies, it brings several advantages in terms of simplifying treatment and improving patient’s adherence. In addition, it appears that by targeting pharmacokinetic parameters, lower immunogenicity, and achievement of pharmacokinetic-pharmacodynamic targets can be achieved and thus, likely improve treatment outcomes.
Keywords
pharmacokinetics, monoclonal antibodies, pharmacodynamics, subcutaneous administrationTo read this article in full, please register for free on this website.
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