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Gastroenterologie
a hepatologie

Gastroenterology and Hepatology

Gastroent Hepatol 2025; 79(3): 191–196. doi: 10.48095/ccgh2025191.

Multiple transluminal gateway technique in endoscopic ultrasound-guided drainage of walled-off pancreatic necrosis – a case report

Iva Rennétová1, Jiřina Pintová Orcid.org  2

+ Affiliation

Summary

Acute pancreatitis is an inflammatory disease of the pancreas. In most patients, it occurs in a mild form with spontaneous regression. However, some patients develop severe necrotizing pancreatitis. The aim of this case report is to demonstrate the possibilities of interventional treatment of peripancreatic fluid collections. These collections arise as complications of acute pancreatitis. We present the case of a 41-year- -old man with biliary pancreatitis who developed multiple infected walled-off pancreatic necroses (WON). After conservative treatment failed, endoscopic ultrasound (EUS) -guided drainage of three large collections was done. The procedure used the multiple transluminal gateway technique (MTGT) with lumen-apposing metal stents (LAMS). As the clinical response to drainage was insufficient, endoscopic necrosectomy was subsequently performed. The procedure was carried out using the EndoRotor device, allowing for easier removal of necrotic tissue. The therapy led to gradual regression of the collections, clinical stabilization, and complete recovery of the patient. This treatment follows the “step-up approach”, starting with less invasive methods and progressing to more invasive ones. The MTGT technique has proven to be effective especially in cases with multiple or extensive collections, where a single-access approach would be insufficient, as demonstrated in this case report.

Keywords

endoscopic drainage, lumen-apposing metal stents, walled-off pancreatic necrosis, pancreatic fluid collection

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Literature

1. Xiao AY, Tan ML, Wu LM et al. Global incidence and mortality of pancreatic diseases: a systematic review, meta-analysis, and meta-regression of population-based cohort studies. Lancet Gastroenterol Hepatol 2016; 1(1): 45–55. doi: 10.1016/S2468-1253(16)30004-8.
2. Banks PA, Bollen TL, Dervenis C et al. Classification of acute pancreatitis – 2012: revision of the Atlanta classification and definitions by international consensus. Gut 2013; 62(1): 102–111. doi: 10.1136/gutjnl-2012-302779.
3. Arvanitakis M, Dumonceau JM, Albert J et al. Endoscopic management of acute necrotizing pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) evidence-based multidisciplinary guidelines. Endoscopy 2018; 50(6): 524–546. doi: 10.1055/a-0588-5365.
4. Maňák J, Rejchrt S, Andrašina T et al. Těžká akutní pankreatitida. 2022 [online]. Dostupné z: https: //kdp.uzis.cz/res/guideline/37-tezka-akutni-pankreatitida-final.pdf.
5. van Santvoort HC, Besselink MG, Bakker OJ et al. A step-up approach or open necrosectomy for necrotizing pancreatitis. N Engl J Med 2010; 362(16): 1491–1502. doi: 10.1056/NEJMoa0908821.
6. Husťák R, Martínek J. Pankreatická nekróza a tekutinové kolekce. In: Martínek J, Trunečka P (eds). Gastroenterologie a hepatologie v algoritmech. Praha: Maxdorf 2021: 435–442.
7. van Brunschot S, van Grinsven J, van Santvoort HC et al. Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial. Lancet 2018; 391(10115): 51–58. doi: 10.1016/S0140-6736(17)32404-2.
8. Bang JY, Wilcox CM, Arnoletti JP et al. Superiority of endoscopic interventions over minimally invasive surgery for infected necrotizing pancreatitis: meta-analysis of randomized trials. Dig Endosc 2020; 32(3): 298–308. doi: 10.1111/den.13470.
9. Varadarajulu S, Christein JD, Tamhane A et al. Prospective randomized trial comparing EUS and EGD for transmural drainage of pancreatic pseudocysts (with videos). Gastrointest Endosc 2008; 68(6): 1102–1111. doi: 10.1016/j.gie.2008.04.028.
10. Moon SH, Choi SY, Jung SW et al. Endoscopic ultrasound-guided versus conventional transmural drainage for pancreatic pseudocysts: a prospective randomized trial. Endoscopy 2009; 41(10): 842–848. doi: 10.1055/s-0029-1215133.
11. Binmoeller KF, Shah J. A novel lumen-apposing stent for transluminal drainage of nonadherent extraintestinal fluid collections. Endoscopy 2011; 43(4): 337–342. doi: 10.1055/s-0030-1256127.
12. Štěpán M, Urban O, Fojtík P, et al. Migrace samoexpandibilního metalického stentu do drénované pseudocysty po endoskopické pseudocystogastrostomii a jeho endoskopická extrakce. Gastroent Hepatol 2018; 72(3): 221–224. doi: 10.14735/amgh2018221.
13. Pintová J, Procházka R, Nosek V. Endosonograficky navigované drenážní výkony novými metalickými apozičními stenty s elektrokauterizační jednotkou (stent Hot AXIOS) – vlastní soubor 20 pacientů. Gastroent Hepatol 2018; 72(4): 309–316. doi: 10.14735/amgh2018309.
14. Bang JY, Hawes R, Bartolucci A et al. Efficacy of metal and plastic stents for transmural drainage of pancreatic fluid collections: a systematic review. Dig Endosc 2015; 27(4): 486–498. doi: 10.1111/den.12418.
15. Bang JY, Navaneethan U, Hasan MK et al. Non-superiority of lumen-apposing metal stents over plastic stents for drainage of walled-off necrosis in a randomised trial. Gut 2019; 68(7): 1200–1209. doi: 10.1136/gutjnl-2017-315335.
16. Lang GD, Fritz C, Bhat T et al. EUS-guided drainage of peripancreatic fluid collections with lumen-apposing metal stents and plastic double-pigtail stents: comparison of efficacy and adverse event rates. Gastrointest Endosc 2018; 87(1): 150–157. doi: 10.1016/j.gie.2017.06.029.
17. Poc K, Mačinga P, Štirand P et al. Endosonograficky navigovaná drenáž pankreatických kolekcí – vlastní zkušenosti. Gastroent Hepatol 2017; 71(5): 401–408. doi: 10.14735/amgh2017401.
18. Vanek P, Falt P, Vitek P et al. EUS-guided transluminal drainage using lumen-apposing metal stents with or without coaxial plastic stents for treatment of walled-off necrotizing pancreatitis: a prospective bicentric randomized controlled trial. Gastrointest Endosc 2023; 97(6): 1070–1080. doi: 10.1016/j.gie.2022.12.026.
19. Varadarajulu S, Phadnis MA, Christein JD et al. Multiple transluminal gateway technique for EUS-guided drainage of symptomatic walled-off pancreatic necrosis. Gastrointest Endosc 2011; 74(1): 74–80. doi: 10.1016/j.gie.2011.03.1122.
20. Binda C, Dabizzi E, Anderloni A et al. Single-step endoscopic ultrasound-guided multiple gateway drainage of complex walled-off necrosis with lumen apposing metal stents. Eur J Gastroenterol Hepatol 2020; 32(10): 1401–1404. doi: 10.1097/MEG.0000000000001793.
21. Yan L, Dargan A, Nieto J et al. Direct endoscopic necrosectomy at the time of transmural stent placement results in earlier resolution of complex walled-off pancreatic necrosis: results from a large multicenter United States trial. Endosc Ultrasound 2019; 8(3): 172–179. doi: 10.4103/eus.eus_108_17.
22. Bang JY, Lakhtakia S, Thakkar S et al. Upfront endoscopic necrosectomy or step-up endoscopic approach for infected necrotising pancreatitis (DESTIN): a single-blinded, multicentre, randomised trial. Lancet Gastroenterol Hepatol 2024; 9(1): 22–33. doi: 10.1016/S2468-1253(23)00331-X.
23. Binda C, Fabbri S, Perini B et al. Endoscopic ultrasound-guided drainage of pancreatic fluid collections: not all queries are already solved. Medicina 2024; 60(2): 333. doi: 10.3390/medicina60020333.
24. Stassen PMC, de Jonge PJF, Bruno MJ et al. Safety and efficacy of a novel resection system for direct endoscopic necrosectomy of walled-off pancreas necrosis: a prospective, international, multicenter trial. Gastrointest Endosc 2022; 95(3): 471–479. doi: 10.1016/j.gie.2021.09.025.

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