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Gastroenterologie
a hepatologie

Gastroenterology and Hepatology

Gastroent Hepatol 2023; 77(1): 52–56. doi: 10.48095/ccgh202352.

Autoimmune hepatitis after vaccination against COVID-19

Veronika Pítová1, Jan Šperl Orcid.org  1, Pavel Taimr Orcid.org  1, Ondřej Fabián2, Tomáš Miřejovský3, Libor Janoušek Orcid.org  4, Jaroslav Chlupáč5,6, Julius Špičák Orcid.org  1, Soňa Fraňková Orcid.org  1

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Summary

In this case report, we present a 61-year-old patient admitted to the hospital because of tiredness and jaundice less than three weeks after vaccination against SARS-CoV-2 with the first dose of the Comirnaty vaccine (Pfizer/BioNTech). Based on the patient’s medical history, laboratory data, imaging methods and liver bio­psy, we dia­gnosed autoimmune hepatitis. The patient developed acute liver failure, and his liver function did not improve after corticosteroid administration. Therefore, the patient was enrolled in the waiting list and underwent a successful orthotopic liver transplantation.

Keywords

autoimunitní hepatitida, COVID-19, vaccination

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Literature

1. Bril F, Al Diffalha S, Dean M et al. Autoimmune hepatitis developing after coronavirus disease 2019 (COVID-19) vaccine: Causality or casualty? J Hepatol 2021; 75(1): 222–224. doi: 10.1016/j.jhep.2021.04.003.
2. Sasaki T, Suzuki Y, Ishida K et al. Autoimmune hepatitis following influenza virus vaccination: Two case reports. Medicine (Baltimore) 2018; 97(30): e11621. doi: 10.1097/MD.0000000000011621.
3. Berry PA, Smith-Laing G. Hepatitis A vaccine associated with autoimmune hepatitis. World J Gastroenterol 2007; 13(15): 2238–2239. doi: 10.3748/wjg.v13.i15.2238.
4. Segal Y, Shoenfeld Y. Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction. Cell Mol Immunol 2018; 15(6): 586–594. doi: 10.1038/cmi.2017.151.
5. Vojdani A, Kharrazian D. Potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an in­crease in autoimmune diseases. Clin Immunol 2020; 217: 108480. doi: 10.1016/j.clim.2020.108 480.
6. Londoño MC, Gratacós-Ginès J, Sáez-Peñataro J. Another case of autoimmune hepatitis after SARS-CoV-2 vaccination – still casualty? J Hepatol 2021; 75(5): 1248–1249. doi: 10.1016/j.jhep.2021.06.004.
7. Clayton-Chubb D, Schneider D, Freeman E et al. Autoimmune hepatitis developing after the ChAdOx1 nCoV-19 (Oxford-AstraZeneca) vaccine. J Hepatol 2021; 75(5): 1249–1250. doi: 10.1016/j.jhep.2021.06.014.
8. Tan CK, Wong YJ, Wang LM et al. Autoimmune hepatitis following COVID-19 vaccination: True causality or mere association? J Hepatol 2021; 75(5): 1250–1252. doi: 10.1016/j.jhep.2021.06.009.
9. McShane C, Kiat C, Rigby J et al. The mRNA COVID-19 vaccine – A rare trigger of autoimmune hepatitis? J Hepatol 2021; 75(5): 1252–1254. doi: 10.1016/j.jhep.2021.06.044.
10. Lodato F, Larocca A, D‘Errico A et al. An unusual case of acute cholestatic hepatitis after m-RNABNT162b2 (Comirnaty) SARS-CoV-2 vaccine: Coincidence, autoimmunity or drug-related liver injury. J Hepatol 2021; 75(5): 1254–1256. doi: 10.1016/j.jhep.2021.07.005.
11. Rocco A, Sgamato C, Compare D et al. Autoimmune hepatitis following SARS-CoV-2 vaccine: May not be a casualty. J Hepatol 2021; 75(3): 728–729. doi: 10.1016/j.jhep.2021.05.038.
12. Rela M, Jothimani D, Vij M et al. Auto-immune hepatitis following COVID vaccination. J Autoimmun 2021; 123: 102688. doi: 10.1016/j.jaut.2021.102688.
13. Vuille-Lessard É, Montani M, Bosch J et al. Autoimmune hepatitis triggered by SARS-CoV-2 vaccination. J Autoimmun 2021; 123: 102710. doi: 10.1016/j.jaut.2021.102710.
14. Ghielmetti M, Schaufelberger HD, Mieli-Vergani G et al. Acute autoimmune-like hepatitis with atypical anti-mitochondrial antibody after mRNA COVID-19 vaccination: A novel clinical entity? J Autoimmun 2021; 123: 102706. doi: 10.1016/j.jaut.2021.102706.
15. Avci E, Abasiyanik F. Autoimmune hepatitis after SARS-CoV-2 vaccine: New-onset or flare-up? J Autoimmun 2021; 125: 102745. doi: 10.1016/j.jaut.2021.102745.
16. Garrido I, Lopes S, Simões MS et al. Autoimmune hepatitis after COVID-19 vaccine – more than a coincidence. J Autoimmun 2021; 125: 102741. doi: 10.1016/j.jaut.2021.102741.
17. Pinazo-Bandera JM, Hernández-Albújar A, García-Salguero AI et al. Acute hepatitis with autoimmune features after COVID-19 vaccine: coincidence or vaccine-induced phenomenon? Gastroenterol Rep (Oxf) 2022; 10: goac014. doi: 10.1093/gastro/goac014.
18. Camacho-Domínguez L, Rodríguez Y, Polo F et al. COVID-19 vaccine and autoimmunity. A new case of autoimmune hepatitis and review of the literature. J Transl Autoimmun 2022; 5: 100140. doi: 10.1016/j.jtauto.2022.100140.
19. Erard D, Villeret F, Lavrut PM et al. Autoimmune hepatitis developing after COVID 19 vaccine: Presumed guilty? Clin Res Hepatol Gastroenterol 2022; 46(3): 101841. doi: 10.1016/j.clinre.2021.101841.

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